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5euq

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<StructureSection load='5euq' size='340' side='right' caption='[[5euq]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5euq' size='340' side='right' caption='[[5euq]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5euq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EUQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5euq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EUQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5S8:~{N}-[5-[3-[[(4-HYDROXYPHENYL)AMINO]-BIS(OXIDANYL)-$L^{4}-SULFANYL]-4-METHOXY-PHENYL]-4-METHYL-1,3-THIAZOL-2-YL]CYCLOPENTANECARBOXAMIDE'>5S8</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5S8:~{N}-[5-[3-[[(4-HYDROXYPHENYL)AMINO]-BIS(OXIDANYL)-$L^{4}-SULFANYL]-4-METHOXY-PHENYL]-4-METHYL-1,3-THIAZOL-2-YL]CYCLOPENTANECARBOXAMIDE'>5S8</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB11A, RAB11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PI4KB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5euq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5euq OCA], [http://pdbe.org/5euq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5euq RCSB], [http://www.ebi.ac.uk/pdbsum/5euq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5euq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5euq OCA], [http://pdbe.org/5euq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5euq RCSB], [http://www.ebi.ac.uk/pdbsum/5euq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5euq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</StructureSection>
</StructureSection>
[[Category: 1-phosphatidylinositol 4-kinase]]
[[Category: 1-phosphatidylinositol 4-kinase]]
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[[Category: Human]]
[[Category: Burke, J E]]
[[Category: Burke, J E]]
[[Category: Fowler, M L]]
[[Category: Fowler, M L]]

Revision as of 09:55, 22 November 2017

Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a potent and selective inhibitor in complex with GDP loaded Rab11

5euq, resolution 3.20Å

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