5hi4
From Proteopedia
(Difference between revisions)
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<StructureSection load='5hi4' size='340' side='right' caption='[[5hi4]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='5hi4' size='340' side='right' caption='[[5hi4]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5hi4]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HI4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5hi4]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HI4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63P:(9S,17R)-6-chloro-N-methyl-9-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-10,19-dioxo-2-oxa-11,18-diazaspiro[cyclopentane-1,21-tetracyclo[20.2.2.2~12,15~.1~3,7~]nonacosane]-1(24),3(29),4,6,12,14,22,25,27-nonaene-17-carboxamide'>63P</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63P:(9S,17R)-6-chloro-N-methyl-9-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-10,19-dioxo-2-oxa-11,18-diazaspiro[cyclopentane-1,21-tetracyclo[20.2.2.2~12,15~.1~3,7~]nonacosane]-1(24),3(29),4,6,12,14,22,25,27-nonaene-17-carboxamide'>63P</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hhv|5hhv]], [[5hhx|5hhx]], [[5hi3|5hi3]], [[5hi5|5hi5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hhv|5hhv]], [[5hhx|5hhx]], [[5hi3|5hi3]], [[5hi5|5hi5]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL17A, CTLA8, IL17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi4 OCA], [http://pdbe.org/5hi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hi4 RCSB], [http://www.ebi.ac.uk/pdbsum/5hi4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hi4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi4 OCA], [http://pdbe.org/5hi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hi4 RCSB], [http://www.ebi.ac.uk/pdbsum/5hi4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hi4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Liu, S]] | [[Category: Liu, S]] | ||
[[Category: Il-17a]] | [[Category: Il-17a]] | ||
Revision as of 09:59, 22 November 2017
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
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