5hi5

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<StructureSection load='5hi5' size='340' side='right' caption='[[5hi5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5hi5' size='340' side='right' caption='[[5hi5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hi5]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HI5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hi5]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HI5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63Q:(4S,20R)-7-CHLORO-N-METHYL-4-{[(1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]AMINO}-3,18-DIOXO-2,19-DIAZATETRACYCLO[20.2.2.1~6,10~.1~11,15~]OCTACOSA-1(24),6(28),7,9,11(27),12,14,22,25-NONAENE-20-CARBOXAMIDE'>63Q</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63Q:(4S,20R)-7-CHLORO-N-METHYL-4-{[(1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]AMINO}-3,18-DIOXO-2,19-DIAZATETRACYCLO[20.2.2.1~6,10~.1~11,15~]OCTACOSA-1(24),6(28),7,9,11(27),12,14,22,25-NONAENE-20-CARBOXAMIDE'>63Q</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hhv|5hhv]], [[5hhx|5hhx]], [[5hi3|5hi3]], [[5hi4|5hi4]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hhv|5hhv]], [[5hhx|5hhx]], [[5hi3|5hi3]], [[5hi4|5hi4]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL17A, CTLA8, IL17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi5 OCA], [http://pdbe.org/5hi5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hi5 RCSB], [http://www.ebi.ac.uk/pdbsum/5hi5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hi5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi5 OCA], [http://pdbe.org/5hi5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hi5 RCSB], [http://www.ebi.ac.uk/pdbsum/5hi5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hi5 ProSAT]</span></td></tr>
</table>
</table>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
[[Category: Liu, S]]
[[Category: Liu, S]]
[[Category: Il-17a]]
[[Category: Il-17a]]

Revision as of 09:59, 22 November 2017

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

5hi5, resolution 1.80Å

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