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5tpg
From Proteopedia
(Difference between revisions)
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<StructureSection load='5tpg' size='340' side='right' caption='[[5tpg]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='5tpg' size='340' side='right' caption='[[5tpg]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5tpg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TPG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5tpg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TPG FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7H5:(3S)-8-(2-AMINO-6-{(1R)-1-[5-CHLORO-3-(METHYLSULFONYL)[1,1-BIPHENYL]-2-YL]-2,2,2-TRIFLUOROETHOXY}PYRIMIDIN-4-YL)-2,8-DIAZASPIRO[4.5]DECANE-3-CARBOXYLIC+ACID'>7H5</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7H5:(3S)-8-(2-AMINO-6-{(1R)-1-[5-CHLORO-3-(METHYLSULFONYL)[1,1-BIPHENYL]-2-YL]-2,2,2-TRIFLUOROETHOXY}PYRIMIDIN-4-YL)-2,8-DIAZASPIRO[4.5]DECANE-3-CARBOXYLIC+ACID'>7H5</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5l01|5l01]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5l01|5l01]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TPH1, TPH, TPRH, TRPH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpg OCA], [http://pdbe.org/5tpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tpg RCSB], [http://www.ebi.ac.uk/pdbsum/5tpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpg ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpg OCA], [http://pdbe.org/5tpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tpg RCSB], [http://www.ebi.ac.uk/pdbsum/5tpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpg ProSAT]</span></td></tr> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Tryptophan 5-monooxygenase]] | [[Category: Tryptophan 5-monooxygenase]] | ||
[[Category: Goldberg, D R]] | [[Category: Goldberg, D R]] | ||
Revision as of 10:17, 22 November 2017
Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors
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