UMP/CMP kinase
From Proteopedia
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| + | <StructureSection load='5kud' size='350' side='right' caption='Structure of UMP/CMP kinase complex with SDP and CMP (PDB entry [[5kud]])' scene=''> | ||
| + | __TOC__ | ||
| + | == Function == | ||
| + | '''UMP/CMP kinase''' (UCK) or '''uridylmonophosphate/cytidylmonophosphate kinase''' phosphorylates UMP, CMP and deoxy-CMP<ref>PMID:12694191</ref>. | ||
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| + | == Relevance == | ||
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| + | everal cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK<ref>PMID:11912132</ref>. | ||
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| + | == Structural highlights == | ||
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| + | </StructureSection> | ||
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| + | == 3D Structures of UMP/CMP kinase == | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | [[2ukd]], [[3ukd]], [[1qf9]], [[5ukd]] – smUCK + ADP + CMP – slime mold <br /> | ||
| + | [[4ukd]] – smUCK + ADP + UDP <br /> | ||
| + | [[1uke]] – smUCK + inhibitor<br /> | ||
| + | [[1tev]] – UCK – human <br /> | ||
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| + | == References == | ||
| + | <references/> | ||
| + | [[Category:Topic Page]] | ||
Revision as of 11:09, 23 November 2017
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3D Structures of UMP/CMP kinase
Updated on 23-November-2017
2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor
1tev – UCK – human
References
- ↑ Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191
- ↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132
