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5h7r
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain== | |
| - | + | <StructureSection load='5h7r' size='340' side='right' caption='[[5h7r]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h7r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H7R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h7s|5h7s]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h7r OCA], [http://pdbe.org/5h7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h7r RCSB], [http://www.ebi.ac.uk/pdbsum/5h7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h7r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LNX1_HUMAN LNX1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity). Isoform 2 provides an endocytic scaffold for IGSF5/JAM4 (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Nayak, D]] | ||
[[Category: Sivaraman, J]] | [[Category: Sivaraman, J]] | ||
| - | [[Category: | + | [[Category: E3 ligase]] |
| + | [[Category: Ligase]] | ||
| + | [[Category: Ring]] | ||
| + | [[Category: Ubiquitination]] | ||
| + | [[Category: Zn finger motif]] | ||
Revision as of 06:05, 29 November 2017
Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain
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Categories: Nayak, D | Sivaraman, J | E3 ligase | Ligase | Ring | Ubiquitination | Zn finger motif
