5nmt
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Dimer structure of Sortilin ectodomain crystal form 1, 2.3A== | |
| - | + | <StructureSection load='5nmt' size='340' side='right' caption='[[5nmt]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nmt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NMT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nmt OCA], [http://pdbe.org/5nmt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nmt RCSB], [http://www.ebi.ac.uk/pdbsum/5nmt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nmt ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SORT_MOUSE SORT_MOUSE]] Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.<ref>PMID:10594043</ref> <ref>PMID:15236332</ref> <ref>PMID:15236333</ref> <ref>PMID:15372498</ref> <ref>PMID:15992544</ref> <ref>PMID:19407813</ref> <ref>PMID:21102451</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Janssen, B J.C]] | ||
| + | [[Category: Leloup, N O.L]] | ||
| + | [[Category: Acidic ph]] | ||
| + | [[Category: Dimer]] | ||
| + | [[Category: Sorting receptor]] | ||
| + | [[Category: Transport protein]] | ||
| + | [[Category: Vps10 domain]] | ||
Revision as of 06:07, 29 November 2017
Dimer structure of Sortilin ectodomain crystal form 1, 2.3A
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