2bx9
From Proteopedia
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|PDB= 2bx9 |SIZE=350|CAPTION= <scene name='initialview01'>2bx9</scene>, resolution 2.80Å | |PDB= 2bx9 |SIZE=350|CAPTION= <scene name='initialview01'>2bx9</scene>, resolution 2.80Å | ||
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+L'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+L'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bx9 OCA], [http://www.ebi.ac.uk/pdbsum/2bx9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bx9 RCSB]</span> | ||
}} | }} | ||
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[[Category: Gollnick, P.]] | [[Category: Gollnick, P.]] | ||
[[Category: Shevtsov, M B.]] | [[Category: Shevtsov, M B.]] | ||
| - | [[Category: ZN]] | ||
[[Category: anti-trap]] | [[Category: anti-trap]] | ||
[[Category: at]] | [[Category: at]] | ||
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[[Category: trp rna-binding attenuation protein]] | [[Category: trp rna-binding attenuation protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:13:07 2008'' |
Revision as of 23:13, 30 March 2008
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| , resolution 2.80Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF B.SUBTILIS ANTI-TRAP PROTEIN, AN ANTAGONIST OF TRAP-RNA INTERACTIONS
Overview
In Bacillus subtilis the anti-TRAP protein (AT) is produced in response to the accumulation of uncharged tRNA(Trp). AT regulates expression of genes involved in tryptophan biosynthesis and transport by binding to the tryptophan-activated trp RNA-binding attenuation protein (TRAP) and preventing its interaction with several mRNAs. Here, we report the x-ray structure of AT at 2.8 angstroms resolution, showing that the protein subunits assemble into tight trimers. Four such trimers are further associated into a 12-subunit particle in which individual trimers are related by twofold and threefold symmetry axes. Twelve DnaJ-like, cysteine-rich zinc-binding domains form spikes on the surface of the dodecamer. Available data suggest several possible ways for AT to interact with the 11-subunit TRAP. Interaction between the two symmetry-mismatching molecules could be assisted by the flexible nature of AT zinc-binding domains.
About this Structure
2BX9 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Crystal structure of Bacillus subtilis anti-TRAP protein, an antagonist of TRAP/RNA interaction., Shevtsov MB, Chen Y, Gollnick P, Antson AA, Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17600-5. Epub 2005 Nov 23. PMID:16306262
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