User:Juliet Obi/Sandbox 1

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Overview

Bromodomain adjacent to zinc finger 1A (BAZ1A) is a protein in humans encoded by the BAZ1A gene. The protein encoded by the BAZ1A gene contains the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), which is a member of the imitation switch (ISWI) family of chromatin remodeling complexes including BAZ1B. BAZ1A structure contains a plant homeodomain (PHD) zinc finger at the N-terminus, a bromodomain at the C-terminus, a WAKZ motif and a LH (leucine-rich helical domain) motif ^[1]. BAZ1A is also known as ACF1, WALp1, hACF1 or WCRF180 ^[2].

BAZ1A function

Role in chromatin remodelling

Structural features

Evolution and related structures

Ligand-interaction domain

DNA binding

Medical implications

References

1. ↑ Jones MH, Hamana N, Nezu Ji, Shimane M. A novel family of bromodomain genes. Genomics. 2000 Jan 1;63(1):40-5. doi: 10.1006/geno.1999.6071. PMID:10662543 doi:http://dx.doi.org/10.1006/geno.1999.6071
2. ↑ Racki LR, Yang JG, Naber N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar GJ. The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. Nature. 2009 Dec 24;462(7276):1016-21. doi: 10.1038/nature08621. PMID:20033039 doi:http://dx.doi.org/10.1038/nature08621

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