2bze

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bze OCA], [http://www.ebi.ac.uk/pdbsum/2bze PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bze RCSB]</span>
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[[Category: transcription regulation]]
[[Category: transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:08:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:03 2008''

Revision as of 23:14, 30 March 2008

Image:2bze.gif


PDB ID 2bze

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Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



NMR STRUCTURE OF HUMAN RTF1 PLUS3 DOMAIN.


Overview

The yeast Paf1 complex consists of Paf1, Rtf1, Cdc73, Ctr9, and Leo1 and regulates histone H2B ubiquitination, histone H3 methylation, RNA polymerase II carboxy-terminal domain (CTD) Ser2 phosphorylation, and RNA 3' end processing. We provide structural insight into the Paf1 complex with the NMR structure of the conserved and functionally important Plus3 domain of human Rtf1. A predominantly beta-stranded subdomain displays structural similarity to Dicer/Argonaute PAZ domains and to Tudor domains. We further demonstrate that the highly basic Rtf1 Plus3 domain can interact in vitro with single-stranded DNA via residues on the rim of the beta sheet, reminiscent of siRNA binding by PAZ domains, but did not detect binding to double-stranded DNA or RNA. We discuss the potential role of Rtf1 Plus3 ssDNA binding during transcription elongation.

About this Structure

2BZE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and DNA binding of the human Rtf1 Plus3 domain., de Jong RN, Truffault V, Diercks T, Ab E, Daniels MA, Kaptein R, Folkers GE, Structure. 2008 Jan;16(1):149-59. PMID:18184592

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