2bzf
From Proteopedia
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|PDB= 2bzf |SIZE=350|CAPTION= <scene name='initialview01'>2bzf</scene>, resolution 2.87Å | |PDB= 2bzf |SIZE=350|CAPTION= <scene name='initialview01'>2bzf</scene>, resolution 2.87Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzf OCA], [http://www.ebi.ac.uk/pdbsum/2bzf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bzf RCSB]</span> | ||
}} | }} | ||
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==Overview== | ==Overview== | ||
The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes. To better understand this behavior, we solved the crystal structure of BAF bound to DNA. The structure reveals that BAF bridges DNA using two pairs of helix-hairpin-helix motifs located on opposite surfaces of the BAF dimer without changing its conformation. | The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes. To better understand this behavior, we solved the crystal structure of BAF bound to DNA. The structure reveals that BAF bridges DNA using two pairs of helix-hairpin-helix motifs located on opposite surfaces of the BAF dimer without changing its conformation. | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Epilepsy, myoclonic, benign adult familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601068 601068]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: retroviral integration]] | [[Category: retroviral integration]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:05 2008'' |
Revision as of 23:14, 30 March 2008
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| , resolution 2.87Å | |||||||
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| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURAL BASIS FOR DNA BRIDGING BY BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)
Overview
The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes. To better understand this behavior, we solved the crystal structure of BAF bound to DNA. The structure reveals that BAF bridges DNA using two pairs of helix-hairpin-helix motifs located on opposite surfaces of the BAF dimer without changing its conformation.
About this Structure
2BZF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for DNA bridging by barrier-to-autointegration factor., Bradley CM, Ronning DR, Ghirlando R, Craigie R, Dyda F, Nat Struct Mol Biol. 2005 Oct;12(10):935-6. Epub 2005 Sep 11. PMID:16155580
Page seeded by OCA on Mon Mar 31 02:14:05 2008
