2c0i
From Proteopedia
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|PDB= 2c0i |SIZE=350|CAPTION= <scene name='initialview01'>2c0i</scene>, resolution 2.30Å | |PDB= 2c0i |SIZE=350|CAPTION= <scene name='initialview01'>2c0i</scene>, resolution 2.30Å | ||
|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+A'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+A'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=L1G:N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE'>L1G</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/ | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0i OCA], [http://www.ebi.ac.uk/pdbsum/2c0i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c0i RCSB]</span> | ||
}} | }} | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: | + | [[Category: Transferase]] |
[[Category: Borhani, D W.]] | [[Category: Borhani, D W.]] | ||
[[Category: Burchat, A.]] | [[Category: Burchat, A.]] | ||
| Line 29: | Line 32: | ||
[[Category: Li, B.]] | [[Category: Li, B.]] | ||
[[Category: Loew, A.]] | [[Category: Loew, A.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: L1G]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
[[Category: kinase]] | [[Category: kinase]] | ||
| Line 43: | Line 44: | ||
[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:35 2008'' |
Revision as of 23:14, 30 March 2008
| |||||||
| , resolution 2.30Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983
Overview
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
About this Structure
2C0I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
Page seeded by OCA on Mon Mar 31 02:14:35 2008
