5ybj

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m (Protected "5ybj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5ybj is ON HOLD until Paper Publication
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==Structure of apo KANK1 ankyrin domain==
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<StructureSection load='5ybj' size='340' side='right' caption='[[5ybj]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ybj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YBJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ybj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybj OCA], [http://pdbe.org/5ybj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ybj RCSB], [http://www.ebi.ac.uk/pdbsum/5ybj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybj ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/KANK1_HUMAN KANK1_HUMAN]] Inherited congenital spastic tetraplegia. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/KANK1_HUMAN KANK1_HUMAN]] Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.<ref>PMID:16968744</ref> <ref>PMID:18458160</ref> <ref>PMID:19171758</ref> <ref>PMID:22084092</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Guo, Q]]
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[[Category: Liao, S]]
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[[Category: Min, J]]
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[[Category: Structural genomic]]
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[[Category: Xu, C]]
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[[Category: Cell adhesion]]

Revision as of 07:22, 6 December 2017

Structure of apo KANK1 ankyrin domain

5ybj, resolution 2.34Å

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