5ybu

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m (Protected "5ybu" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5ybu is ON HOLD until Paper Publication
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==Structure of the KANK1 ankyrin domain in complex with KIF21A peptide==
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<StructureSection load='5ybu' size='340' side='right' caption='[[5ybu]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ybu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YBU FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ybu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ybu OCA], [http://pdbe.org/5ybu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ybu RCSB], [http://www.ebi.ac.uk/pdbsum/5ybu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ybu ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/KANK1_HUMAN KANK1_HUMAN]] Inherited congenital spastic tetraplegia. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Congenital fibrosis of extraocular muscles. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/KANK1_HUMAN KANK1_HUMAN]] Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.<ref>PMID:16968744</ref> <ref>PMID:18458160</ref> <ref>PMID:19171758</ref> <ref>PMID:22084092</ref> [[http://www.uniprot.org/uniprot/KI21A_HUMAN KI21A_HUMAN]] Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Guo, Q]]
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[[Category: Liao, S]]
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[[Category: Min, J]]
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[[Category: Structural genomic]]
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[[Category: Xu, C]]
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[[Category: Cell adhesion]]

Revision as of 07:22, 6 December 2017

Structure of the KANK1 ankyrin domain in complex with KIF21A peptide

5ybu, resolution 1.89Å

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