2c57
From Proteopedia
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|PDB= 2c57 |SIZE=350|CAPTION= <scene name='initialview01'>2c57</scene>, resolution 3.10Å | |PDB= 2c57 |SIZE=350|CAPTION= <scene name='initialview01'>2c57</scene>, resolution 3.10Å | ||
|SITE= <scene name='pdbsite=AC1:Fa1+Binding+Site+For+Chain+L'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Fa1+Binding+Site+For+Chain+L'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=FA1:2,3 -ANHYDRO-QUINIC ACID'>FA1</scene> | + | |LIGAND= <scene name='pdbligand=FA1:2,3+-ANHYDRO-QUINIC+ACID'>FA1</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c57 OCA], [http://www.ebi.ac.uk/pdbsum/2c57 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c57 RCSB]</span> | ||
}} | }} | ||
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[[Category: Lapthorn, A J.]] | [[Category: Lapthorn, A J.]] | ||
[[Category: Robinson, D A.]] | [[Category: Robinson, D A.]] | ||
| - | [[Category: FA1]] | ||
[[Category: 3-dehydroquinase]] | [[Category: 3-dehydroquinase]] | ||
[[Category: aromatic amino acid biosynthesis]] | [[Category: aromatic amino acid biosynthesis]] | ||
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[[Category: sulphonamide]] | [[Category: sulphonamide]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:29 2008'' |
Revision as of 23:16, 30 March 2008
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| , resolution 3.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | |||||||
| Activity: | 3-dehydroquinate dehydratase, with EC number 4.2.1.10 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
H.PYLORI TYPE II DEHYDROQUINASE IN COMPLEX WITH FA1
Overview
The crystal structures of the type II dehydroquinase (DHQase) from Helicobacter pylori in complex with three competitive inhibitors have been determined. The inhibitors are the substrate analogue 2,3-anhydroquinate (FA1), citrate, and an oxoxanthene sulfonamide derivative (AH9095). Despite the very different chemical nature of the inhibitors, in each case the primary point of interaction with the enzyme is via the residues that bind the C1 functionalities of the substrate, 3-dehydroquinate, i.e., N76, H102, I103, and H104. The DHQase/AH9095 complex crystal structure shows that sulfonamides can form a scaffold for nonsubstrate-like inhibitors and identifies a large conserved hydrophobic patch at the entrance to the active site as a locus that can be exploited in the development of new ligands.
About this Structure
2C57 is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.
Reference
Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design., Robinson DA, Stewart KA, Price NC, Chalk PA, Coggins JR, Lapthorn AJ, J Med Chem. 2006 Feb 23;49(4):1282-90. PMID:16480265
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