2c62
From Proteopedia
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|PDB= 2c62 |SIZE=350|CAPTION= <scene name='initialview01'>2c62</scene>, resolution 1.74Å | |PDB= 2c62 |SIZE=350|CAPTION= <scene name='initialview01'>2c62</scene>, resolution 1.74Å | ||
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c62 OCA], [http://www.ebi.ac.uk/pdbsum/2c62 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c62 RCSB]</span> | ||
}} | }} | ||
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[[Category: Moras, D.]] | [[Category: Moras, D.]] | ||
[[Category: Werten, S.]] | [[Category: Werten, S.]] | ||
| - | [[Category: SO4]] | ||
[[Category: activator]] | [[Category: activator]] | ||
[[Category: dna unwinding]] | [[Category: dna unwinding]] | ||
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[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:51 2008'' |
Revision as of 23:16, 30 March 2008
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| , resolution 1.74Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA
Overview
The 1.74-A crystal structure of the human transcription cofactor PC4 in complex with a single-stranded 20-mer oligonucleotide reveals how symmetry-related beta-surfaces of the protein homodimer interact with juxtaposed 5-nucleotide DNA regions running in opposite directions. The structure explains high-affinity binding of PC4 to the complementary strands of unwinding duplex DNA, and it suggests the cofactor may have a role in relaxing negative supercoils or exposing unpaired bases for sequence-specific recognition by other biomolecules.
About this Structure
2C62 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A global transcription cofactor bound to juxtaposed strands of unwound DNA., Werten S, Moras D, Nat Struct Mol Biol. 2006 Feb;13(2):181-2. Epub 2006 Jan 15. PMID:16415882
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