1d2z

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(Difference between revisions)

Revision as of 08:20, 6 December 2017

THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE

Structural highlights

1d2z is a 4 chain structure with sequence from Drome. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[KPEL_DROME] Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.^[1] ^[2] ^[3] ^[4] [TUBE_DROME] Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll. Also has a role in pupal pattern formation.^[5] ^[6] ^[7] ^[8] ^[9]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The interaction of the serine/threonine kinase Pelle and adaptor protein Tube through their N-terminal death domains leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis. Crystal structure of the Pelle and Tube death domain heterodimer reveals that the two death domains adopt a six-helix bundle fold and are arranged in an open-ended linear array with plastic interfaces mediating their interactions. The Tube death domain has an insertion between helices 2 and 3, and a C-terminal tail making significant and indispensable contacts in the heterodimer. In vivo assays of Pelle and Tube mutants confirmed that the integrity of the major heterodimer interface is critical to the activity of these molecules.

Three-dimensional structure of a complex between the death domains of Pelle and Tube.,Xiao T, Towb P, Wasserman SA, Sprang SR Cell. 1999 Nov 24;99(5):545-55. PMID:10589682^[10]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Shelton CA, Wasserman SA. pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell. 1993 Feb 26;72(4):515-25. PMID:8440018
↑ Grosshans J, Bergmann A, Haffter P, Nusslein-Volhard C. Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo. Nature. 1994 Dec 8;372(6506):563-6. PMID:7527496 doi:http://dx.doi.org/10.1038/372563a0
↑ Galindo RL, Edwards DN, Gillespie SK, Wasserman SA. Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos. Development. 1995 Jul;121(7):2209-18. PMID:7635064
↑ Grosshans J, Schnorrer F, Nusslein-Volhard C. Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal. Mech Dev. 1999 Mar;81(1-2):127-38. PMID:10330490
↑ Letsou A, Alexander S, Orth K, Wasserman SA. Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):810-4. PMID:1899484
↑ Letsou A, Alexander S, Wasserman SA. Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo. EMBO J. 1993 Sep;12(9):3449-58. PMID:8253071
↑ Grosshans J, Bergmann A, Haffter P, Nusslein-Volhard C. Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo. Nature. 1994 Dec 8;372(6506):563-6. PMID:7527496 doi:http://dx.doi.org/10.1038/372563a0
↑ Galindo RL, Edwards DN, Gillespie SK, Wasserman SA. Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos. Development. 1995 Jul;121(7):2209-18. PMID:7635064
↑ Schiffmann DA, White JH, Cooper A, Nutley MA, Harding SE, Jumel K, Solari R, Ray KP, Gay NJ. Formation and biochemical characterization of tube/pelle death domain complexes: critical regulators of postreceptor signaling by the Drosophila toll receptor. Biochemistry. 1999 Sep 7;38(36):11722-33. PMID:10512628
↑ Xiao T, Towb P, Wasserman SA, Sprang SR. Three-dimensional structure of a complex between the death domains of Pelle and Tube. Cell. 1999 Nov 24;99(5):545-55. PMID:10589682

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1d2z"

@@ Line 1: / Line 1: @@
 ==THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE==
 <StructureSection load='1d2z' size='340' side='right' caption='[[1d2z]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
@@ Line 4: / Line 5: @@
 <table><tr><td colspan='2'>[[1d2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D2Z FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2z OCA], [http://pdbe.org/1d2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d2z RCSB], [http://www.ebi.ac.uk/pdbsum/1d2z PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2z OCA], [http://pdbe.org/1d2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d2z RCSB], [http://www.ebi.ac.uk/pdbsum/1d2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2z ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 13: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2z_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2z_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>

1d2z

From Proteopedia

Revision as of 08:20, 6 December 2017

THREE-DIMENSIONAL STRUCTURE OF A COMPLEX BETWEEN THE DEATH DOMAINS OF PELLE AND TUBE

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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