5kdi
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==How FAPP2 Selects Simple Glycosphingolipids Using the GLTP-fold== | |
| - | + | <StructureSection load='5kdi' size='340' side='right' caption='[[5kdi]], [[Resolution|resolution]] 1.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kdi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KDI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6S8:(~{Z})-~{N}-[(~{E},2~{S},3~{R})-1-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-octadec-4-en-2-yl]octadec-9-enamide'>6S8</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdi OCA], [http://pdbe.org/5kdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kdi RCSB], [http://www.ebi.ac.uk/pdbsum/5kdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdi ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/PKHA8_HUMAN PKHA8_HUMAN]] Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.<ref>PMID:15107860</ref> <ref>PMID:16103222</ref> <ref>PMID:17687330</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brown, R E]] | ||
[[Category: Malinina, L]] | [[Category: Malinina, L]] | ||
| - | [[Category: Samygina, V.R]] | ||
| - | [[Category: Patel, D.J]] | ||
[[Category: Ochoa-Lizarralde, B]] | [[Category: Ochoa-Lizarralde, B]] | ||
| + | [[Category: Patel, D J]] | ||
| + | [[Category: Popov, A N]] | ||
| + | [[Category: Samygina, V R]] | ||
| + | [[Category: Gltp-fold]] | ||
| + | [[Category: Lipid transfer]] | ||
| + | [[Category: Lipid transport]] | ||
Revision as of 06:53, 13 December 2017
How FAPP2 Selects Simple Glycosphingolipids Using the GLTP-fold
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