5mn2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.== | |
| - | + | <StructureSection load='5mn2' size='340' side='right' caption='[[5mn2]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mn2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MN2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mn2 OCA], [http://pdbe.org/5mn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mn2 RCSB], [http://www.ebi.ac.uk/pdbsum/5mn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mn2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23006327</ref> <ref>PMID:8608639</ref> <ref>PMID:8609432</ref> <ref>PMID:8874200</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN]] Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.<ref>PMID:21768335</ref> <ref>PMID:22023369</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Baxter, E W]] | ||
| + | [[Category: Goldman, A]] | ||
| + | [[Category: Harris, S A]] | ||
| + | [[Category: McPherson, M J]] | ||
| + | [[Category: Morgan, A W]] | ||
| + | [[Category: Nettleship, J E]] | ||
| + | [[Category: Owen, R L]] | ||
| + | [[Category: Owens, R J]] | ||
| + | [[Category: Robinson, J I]] | ||
| + | [[Category: Thomsen, M]] | ||
| + | [[Category: Tiede, C]] | ||
| + | [[Category: Tomlinson, D C]] | ||
| + | [[Category: Waterhouse, M P]] | ||
| + | [[Category: Fc gamma receptor iiia affimer allosteric inhibitor fcgr3a]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 06:53, 13 December 2017
Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.
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