6bqp
From Proteopedia
(Difference between revisions)
m (Protected "6bqp" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Human CAMKK2B in complex with Crenolanib== | |
| - | + | <StructureSection load='6bqp' size='340' side='right' caption='[[6bqp]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bqp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6T2:1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine'>6T2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqp OCA], [http://pdbe.org/6bqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqp RCSB], [http://www.ebi.ac.uk/pdbsum/6bqp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqp ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Calcium/calmodulin-dependent protein kinase]] | ||
| + | [[Category: Arruda, P]] | ||
| + | [[Category: Counago, R M]] | ||
[[Category: Drewry, D]] | [[Category: Drewry, D]] | ||
| - | [[Category: Edwards, A | + | [[Category: Edwards, A M]] |
| - | [[Category: | + | [[Category: Elkins, J M]] |
| - | + | [[Category: Massirer, K B]] | |
| - | [[Category: Massirer, K | + | [[Category: Ramos, P Z]] |
| - | [[Category: Ramos, P | + | [[Category: Reis, C V.dos]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Souza, G P.de]] |
| - | [[Category: | + | [[Category: Protein kinase domain]] |
| + | [[Category: Sgc]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase inhibitor complex]] | ||
Revision as of 07:04, 13 December 2017
Crystal Structure of the Human CAMKK2B in complex with Crenolanib
| |||||||||||
