6bp0

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==Crystal Structure of the Human vaccinia-related kinase 1 bound to pteridine inhibitor==
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==Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridinone inhibitor==
<StructureSection load='6bp0' size='340' side='right' caption='[[6bp0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6bp0' size='340' side='right' caption='[[6bp0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bp0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BP0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bp0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BP0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E1D:(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one'>E1D</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E1D:(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one'>E1D</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bp0 OCA], [http://pdbe.org/6bp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bp0 RCSB], [http://www.ebi.ac.uk/pdbsum/6bp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bp0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bp0 OCA], [http://pdbe.org/6bp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bp0 RCSB], [http://www.ebi.ac.uk/pdbsum/6bp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bp0 ProSAT]</span></td></tr>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arruda, P]]
[[Category: Arruda, P]]
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[[Category: Azevedo, A]]
[[Category: Counago, R M]]
[[Category: Counago, R M]]
[[Category: Edwards, A M]]
[[Category: Edwards, A M]]
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[[Category: Elkins, J M]]
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[[Category: Elkins, J]]
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[[Category: Ferreira, M]]
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[[Category: Gama, F]]
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[[Category: Guimaraes, C]]
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[[Category: Mascarello, A]]
[[Category: Massirer, K B]]
[[Category: Massirer, K B]]
[[Category: Reis, C V.dos]]
[[Category: Reis, C V.dos]]

Revision as of 07:39, 13 December 2017

Crystal Structure of the Human vaccinia-related kinase 1 bound to (R)-2-phenylaminopteridinone inhibitor

6bp0, resolution 1.90Å

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