From Proteopedia

---

Revision as of 08:36, 18 December 2017

proteopedia linkproteopedia link

spinqualitylabelsall models Flagellin complex with TLR5 (PDB code 3v47) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Flagellin (Fla) from Salmonella typhimurium is the major molecular trigger by which the pathogen activates gut epithelial proinflammatory gene expression[1]. Toll-like receptor 5 (TLR5) recognizes bacterial Fla and this association mediates the innate immune response to the bacteria[2]. Structural highlights Fla and TLR5 binding interface is composed in part between the long helices of Fla and the ascending lateral surface of TLR5[3].

3D Structures of flagellin

Updated on 18-December-2017 {{#tree:id=OrganizedByTopic|openlevels=0|

• Flagellin

• • 5o4u – Fla – Pyrococcus furiosus – Cryo EM
    
  • 1ucu, 3a5x – StFla phase1 – Salmonella typhimurium – Cryo EM
    
  • 1io1 – StFla phase1 residues 54-451 (mutant)
    
  • 5wk5, 5wk6 – Fla FliC – Pseudomonas aeruginosa – Cryo EM
    
  • 4nx9 – Fla FliC residues 56-342 (mutant)
    
  • 4cfi – Fla FliC residues 69-326 – Burkholderia pseudomallei
    
  • 4iwb – AaFla FliC/FliS – Aquifex aeolicus
    
  • 5tfy – Fla – Methanospirillum hungatei – Cryo EM
    
  • 5wjt, 5wju, 5wjv, 5wjw, 5wjx, 5wjy, 5wjz – BsFla – Bacillus subtilis – Cryo EM
    

• Flagellin complex

• • 5gna – StFla FliT residues 1-94 + flagellar hook-associated protein 2
    
  • 6b5b – Fla + NAIP5 + NLRC4 – Legionella pneumophila – Cryo EM
    
  • 3v47 – Fla phase1 + TLR5 – Salmonella enterica
    
  • 5gy2 – BsFla residues 54-230 + TLR5
    
  • 1ory – AaFla FliC residues 464-518 + FliS
    

References

1. ↑ Zeng H, Carlson AQ, Guo Y, Yu Y, Collier-Hyams LS, Madara JL, Gewirtz AT, Neish AS. Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol. 2003 Oct 1;171(7):3668-74. PMID:14500664
2. ↑ Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106
3. ↑ Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural basis of TLR5-flagellin recognition and signaling. Science. 2012 Feb 17;335(6070):859-64. PMID:22344444 doi:10.1126/science.1215584