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5m6k

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'''Unreleased structure'''
 
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The entry 5m6k is ON HOLD until Paper Publication
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==Crystal structure of nitrophorin 7 E27V mutant from Rhodnius prolixus with imidazole==
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<StructureSection load='5m6k' size='340' side='right' caption='[[5m6k]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Ogata, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5m6k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M6K FirstGlance]. <br>
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Description: Crystal structure of nitrophorin 7 E27V mutant from Rhodnius prolixus with imidazole
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitrite_dismutase Nitrite dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.6.1 1.7.6.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m6k OCA], [http://pdbe.org/5m6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m6k RCSB], [http://www.ebi.ac.uk/pdbsum/5m6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m6k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NP7_RHOPR NP7_RHOPR]] Converts nitrite as the sole substrate to form nitric oxide gas (NO). NO(2-) serves both as an electron donor and as an electron acceptor. Binds to negatively charged cell surfaces of activated platelets; binds to L-a-phosphatidyl-L-serine (PS)-bearing phospholipid membranes. Once bound on an activated platelet, NP7 releases its stored nitric oxide gas (NO) into the victim's tissues while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also acts as an anticoagulant by blocking coagulation-factor binding sites. Has antihistamine activity; binds histamine with high affinity.<ref>PMID:15170336</ref> <ref>PMID:15598503</ref> <ref>PMID:17428677</ref> <ref>PMID:17958381</ref> <ref>PMID:19655755</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Nitrite dismutase]]
[[Category: Ogata, H]]
[[Category: Ogata, H]]
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[[Category: Heme protein]]
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[[Category: No transporter]]
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[[Category: Oxidoreductase]]

Revision as of 06:04, 20 December 2017

Crystal structure of nitrophorin 7 E27V mutant from Rhodnius prolixus with imidazole

5m6k, resolution 1.60Å

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