5w6g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human antibody 6649 in complex with influenza hemagglutinin H1 Solomon Islands== | |
| - | + | <StructureSection load='5w6g' size='340' side='right' caption='[[5w6g]], [[Resolution|resolution]] 2.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5w6g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W6G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w6g OCA], [http://pdbe.org/5w6g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w6g RCSB], [http://www.ebi.ac.uk/pdbsum/5w6g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w6g ProSAT]</span></td></tr> |
| - | [[Category: Raymond, D | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/A7UPX0_9INFA A7UPX0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Harrison, S C]] | ||
| + | [[Category: Raymond, D D]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: Fab]] | ||
| + | [[Category: Influenza h1n1]] | ||
| + | [[Category: Viral protein-immune system complex]] | ||
Revision as of 06:17, 20 December 2017
Human antibody 6649 in complex with influenza hemagglutinin H1 Solomon Islands
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