5y58

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m (Protected "5y58" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5y58 is ON HOLD until Paper Publication
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==Crystal structure of Ku70/80 and TLC1==
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<StructureSection load='5y58' size='340' side='right' caption='[[5y58]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Chen, H., Xue, J., Wu, J., Lei, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5y58]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y58 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y58 FirstGlance]. <br>
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Description: Crystal structure of Ku70/80 and TLC1
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y58 OCA], [http://pdbe.org/5y58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y58 RCSB], [http://www.ebi.ac.uk/pdbsum/5y58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y58 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KU70_YEAST KU70_YEAST]] Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.<ref>PMID:10675560</ref> <ref>PMID:11046137</ref> <ref>PMID:12138180</ref> <ref>PMID:12975323</ref> <ref>PMID:14585978</ref> <ref>PMID:8626469</ref> <ref>PMID:8668537</ref> <ref>PMID:9635192</ref> <ref>PMID:9635193</ref> <ref>PMID:9663392</ref> <ref>PMID:9914366</ref> [[http://www.uniprot.org/uniprot/KU80_YEAST KU80_YEAST]] Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.<ref>PMID:10675560</ref> <ref>PMID:11046137</ref> <ref>PMID:12138180</ref> <ref>PMID:12975323</ref> <ref>PMID:14551211</ref> <ref>PMID:14585978</ref> <ref>PMID:16166630</ref> <ref>PMID:8910371</ref> <ref>PMID:8972848</ref> <ref>PMID:9563951</ref> <ref>PMID:9635192</ref> <ref>PMID:9635193</ref> <ref>PMID:9663392</ref> <ref>PMID:9914366</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: DNA helicase]]
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[[Category: Chen, H]]
[[Category: Lei, M]]
[[Category: Lei, M]]
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[[Category: Wu, J]]
[[Category: Xue, J]]
[[Category: Xue, J]]
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[[Category: Chen, H]]
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[[Category: Protein-rna complex]]
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[[Category: Wu, J]]
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[[Category: Rna binding protein]]
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[[Category: Telomerase]]
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[[Category: Telomere]]

Revision as of 06:22, 20 December 2017

Crystal structure of Ku70/80 and TLC1

5y58, resolution 2.80Å

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