6bo9
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of human TRPV6 in amphipols== | |
| - | + | <StructureSection load='6bo9' size='340' side='right' caption='[[6bo9]], [[Resolution|resolution]] 4.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bo9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BO9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bo9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bo9 OCA], [http://pdbe.org/6bo9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bo9 RCSB], [http://www.ebi.ac.uk/pdbsum/6bo9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bo9 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRPV6_HUMAN TRPV6_HUMAN]] Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.[UniProtKB:Q91WD2]<ref>PMID:11097838</ref> <ref>PMID:11248124</ref> <ref>PMID:11278579</ref> <ref>PMID:15184369</ref> <ref>PMID:23612980</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Grassucci, R A]] | ||
| + | [[Category: McGoldrick, L L]] | ||
| + | [[Category: Saotome, K]] | ||
| + | [[Category: Singh, A K]] | ||
| + | [[Category: Sobolevsky, A I]] | ||
| + | [[Category: Twomey, E C]] | ||
| + | [[Category: Yelshanskaya, M V]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 06:25, 20 December 2017
Cryo-EM structure of human TRPV6 in amphipols
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