2cjp
From Proteopedia
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|PDB= 2cjp |SIZE=350|CAPTION= <scene name='initialview01'>2cjp</scene>, resolution 1.95Å | |PDB= 2cjp |SIZE=350|CAPTION= <scene name='initialview01'>2cjp</scene>, resolution 1.95Å | ||
|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+B'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+B'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=VPR:2-PROPYLPENTANAMIDE'>VPR</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/ | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Microsomal_epoxide_hydrolase Microsomal epoxide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.9 3.3.2.9] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjp OCA], [http://www.ebi.ac.uk/pdbsum/2cjp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cjp RCSB]</span> | ||
}} | }} | ||
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==Reference== | ==Reference== | ||
X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes., Mowbray SL, Elfstrom LT, Ahlgren KM, Andersson CE, Widersten M, Protein Sci. 2006 Jul;15(7):1628-37. Epub 2006 Jun 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16751602 16751602] | X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes., Mowbray SL, Elfstrom LT, Ahlgren KM, Andersson CE, Widersten M, Protein Sci. 2006 Jul;15(7):1628-37. Epub 2006 Jun 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16751602 16751602] | ||
| + | [[Category: Microsomal epoxide hydrolase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Solanum tuberosum]] | [[Category: Solanum tuberosum]] | ||
| - | [[Category: Transferred entry: 3 3.2 9]] | ||
[[Category: Ahlgren, K M.]] | [[Category: Ahlgren, K M.]] | ||
[[Category: Andersson, C E.]] | [[Category: Andersson, C E.]] | ||
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[[Category: Mowbray, S L.]] | [[Category: Mowbray, S L.]] | ||
[[Category: Widersten, M.]] | [[Category: Widersten, M.]] | ||
| - | [[Category: EDO]] | ||
| - | [[Category: PG4]] | ||
| - | [[Category: VPR]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:22:28 2008'' |
Revision as of 23:22, 30 March 2008
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| , resolution 1.95Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Activity: | Microsomal epoxide hydrolase, with EC number 3.3.2.9 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF POTATO (SOLANUM TUBEROSUM) EPOXIDE HYDROLASE I (STEH1)
Overview
Epoxide hydrolases catalyze the conversion of epoxides to diols. The known functions of such enzymes include detoxification of xenobiotics, drug metabolism, synthesis of signaling compounds, and intermediary metabolism. In plants, epoxide hydrolases are thought to participate in general defense systems. In the present study, we report the first structure of a plant epoxide hydrolase, one of the four homologous enzymes found in potato. The structure was solved by molecular replacement and refined to a resolution of 1.95 A. Analysis of the structure allows a better understanding of the observed substrate specificities and activity. Further, comparisons with mammalian and fungal epoxide hydrolase structures reported earlier show the basis of differing substrate specificities in the various epoxide hydrolase subfamilies. Most plant enzymes, like the potato epoxide hydrolase, are expected to be monomers with a preference for substrates with long lipid-like substituents of the epoxide ring. The significance of these results in the context of biological roles and industrial applications is discussed.
About this Structure
2CJP is a Single protein structure of sequence from Solanum tuberosum. Full crystallographic information is available from OCA.
Reference
X-ray structure of potato epoxide hydrolase sheds light on substrate specificity in plant enzymes., Mowbray SL, Elfstrom LT, Ahlgren KM, Andersson CE, Widersten M, Protein Sci. 2006 Jul;15(7):1628-37. Epub 2006 Jun 2. PMID:16751602
Page seeded by OCA on Mon Mar 31 02:22:28 2008
