2cjq
From Proteopedia
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|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjq OCA], [http://www.ebi.ac.uk/pdbsum/2cjq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cjq RCSB]</span> | ||
}} | }} | ||
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[[Category: viral polymerase]] | [[Category: viral polymerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:22:33 2008'' |
Revision as of 23:22, 30 March 2008
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| , resolution 2.6Å | |||||||
|---|---|---|---|---|---|---|---|
| Activity: | RNA-directed RNA polymerase, with EC number 2.7.7.48 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
BOVINE VIRAL DIARRHEA VIRUS CP7-R12 RNA-DEPENDENT RNA POLYMERASE
Overview
Viral RNA-dependent RNA polymerases (RdRp) differ from DNA-dependent RNA polymerases, DNA-dependent DNA polymerases, and reverse transcriptases in that RdRps contain "fingertips" consisting of several polypeptide strands in the fingers domain interacting with the thumb domain. The crystal structure of bovine viral diarrhea virus (BVDV) RdRp containing an Asn438 duplication shows that the "N-terminal domain," which occurs only in pestiviruses such as BVDV, interacts with the polymerase component of the same polypeptide chain. This contrasts with the domain swapping observed in the previously determined structure of the BVDV NADL strain RdRp. By comparison with the NADL structure and through the use of biochemical data, it is possible that the N-terminal domain, in conjunction with the fingertips, is required to bind and assist the translocation of the RNA template. The partial disorder of the loop containing the additional Asn438 residue may explain the low replication rate of the recombinant compared with the wild-type virus.
About this Structure
2CJQ is a Single protein structure of sequence from Bovine viral diarrhea virus 1. Full crystallographic information is available from OCA.
Reference
The structure of bovine viral diarrhea virus RNA-dependent RNA polymerase and its amino-terminal domain., Choi KH, Gallei A, Becher P, Rossmann MG, Structure. 2006 Jul;14(7):1107-13. PMID:16843892
Page seeded by OCA on Mon Mar 31 02:22:33 2008
Categories: Bovine viral diarrhea virus 1 | RNA-directed RNA polymerase | Single protein | Becher, P. | Choi, K H. | Gallei, A. | Rossmann, M G. | Atp-binding | Bovine viral diarrhea virus | Bvdv | Glycoprotein | Helicase | Hydrolase | Membrane | Nucleotide-binding | Nucleotidyltransferase | Polyprotein | Protease | Rna-dependent rna polymerase | Rna-directed rna polymerase | Serine protease | Thiol protease | Transferase | Transmembrane | Viral polymerase
