6bpq
From Proteopedia
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<StructureSection load='6bpq' size='340' side='right' caption='[[6bpq]], [[Resolution|resolution]] 4.10Å' scene=''> | <StructureSection load='6bpq' size='340' side='right' caption='[[6bpq]], [[Resolution|resolution]] 4.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6bpq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BPQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6bpq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Collared_flycatcher Collared flycatcher]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BPQ FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=59894 Collared flycatcher])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpq OCA], [http://pdbe.org/6bpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bpq RCSB], [http://www.ebi.ac.uk/pdbsum/6bpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpq OCA], [http://pdbe.org/6bpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bpq RCSB], [http://www.ebi.ac.uk/pdbsum/6bpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of physiological processes. Within the TRPM family, member 8 (TRPM8) is the primary cold- and menthol-sensor in humans. We determined the cryo-electron microscopy structure of the full-length TRPM8 from the collared flycatcher at an overall resolution of ~4.1 A. Our TRPM8 structure reveals a three-layered architecture. The amino-terminal domain with a fold distinct among known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cytosolic ring that extensively interacts with the transmembrane channel layer. The structure suggests that the menthol binding site is located within the voltage-sensor-like domain and thus provides a structural glimpse of the design principle of the molecular transducer for cold and menthol sensation. | ||
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| + | Structure of the cold- and menthol-sensing ion channel TRPM8.,Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY Science. 2017 Dec 7. pii: science.aan4325. doi: 10.1126/science.aan4325. PMID:29217583<ref>PMID:29217583</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6bpq" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Collared flycatcher]] | ||
[[Category: Borschel, W F]] | [[Category: Borschel, W F]] | ||
[[Category: Lander, G C]] | [[Category: Lander, G C]] | ||
Revision as of 06:46, 20 December 2017
Structure of the cold- and menthol-sensing ion channel TRPM8
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