Liver receptor homolog-1

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Revision as of 11:24, 21 December 2017

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spinqualitylabelsall models Human LRH-1 (grey) complex with TIF-2 peptide and an agonist (PDB code 5lii) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Liver receptor homolog-1 (LRH-1) is a nuclear receptor which has critical functions in embryonic development and adult homeoestasis. LRH-1 is a key modulator of female fertility. LRH-1 plays a predominant role in development, reverse cholesterol transport, bile-acid homeostasis and steroidogenesis[1]. Relevance LRH-1 is implicated in pancreatic, breast and gastrointestinal cancer where it promotes cell proliferation and metastasis[2]. LRH-1 is a potential target for contraception[3]. Structural highlights The ligand of LRH-1 binds deep in the binding pocket and is fully engulfed by it[4].

3D Structures of liver receptor homolog-1

Updated on 21-December-2017

4is8 – hLRH1 LBD – human
1pk5 – mLRH1 LBD – mouse
3f5c – mLRH1 LBD (mutant) + DAX-1 peptide
3tx7 – hLRH1 LBD + catenin + phospholipid
4pld – hLRH1 LBD + NCOA-2 peptide + phospholipid
1yok, 4dos, 4ple, 1zdu – hLRH1 LBD + NCOA-2 peptide + phospholipid
5l11, 5syz – hLRH1 LBD + NCOA-2 peptide + agonist
4oni, 1yuc – hLRH1 LBD + nuclear receptor 0B2 peptide + phospholipid
1zh7 – hLRH1 LBD + SHP peptide
4dor – hLRH1 LBD + SHP peptide + phospholipid
4rwv – hLRH1 LBD + DAX-1 peptide + phospholipid
5unj – hLRH1 LBD + PGC1A peptide + phospholipid
2a66, 5l0m – hLRH1 DBD + DNA

References

1. ↑ Fayard E, Auwerx J, Schoonjans K. LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Trends Cell Biol. 2004 May;14(5):250-60. doi: 10.1016/j.tcb.2004.03.008. PMID:15130581 doi:http://dx.doi.org/10.1016/j.tcb.2004.03.008
2. ↑ Schoonjans K, Annicotte JS, Huby T, Botrugno OA, Fayard E, Ueda Y, Chapman J, Auwerx J. Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Rep. 2002 Dec;3(12):1181-7. doi: 10.1093/embo-reports/kvf238. Epub 2002 Nov , 21. PMID:12446566 doi:http://dx.doi.org/10.1093/embo-reports/kvf238
3. ↑ Duggavathi R, Volle DH, Mataki C, Antal MC, Messaddeq N, Auwerx J, Murphy BD, Schoonjans K. Liver receptor homolog 1 is essential for ovulation. Genes Dev. 2008 Jul 15;22(14):1871-6. doi: 10.1101/gad.472008. PMID:18628394 doi:http://dx.doi.org/10.1101/gad.472008
4. ↑ Horibata Y, Ando H, Zhang P, Vergnes L, Aoyama C, Itoh M, Reue K, Sugimoto H. StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria. J Biol Chem. 2016 Nov 25;291(48):24880-24891. doi: 10.1074/jbc.M116.736793. Epub , 2016 Sep 30. PMID:27694445 doi:http://dx.doi.org/10.1074/jbc.M116.736793