2cme
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cme OCA], [http://www.ebi.ac.uk/pdbsum/2cme PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cme RCSB]</span> | ||
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[[Category: Meier, C.]] | [[Category: Meier, C.]] | ||
[[Category: Stuart, D I.]] | [[Category: Stuart, D I.]] | ||
| - | [[Category: D10]] | ||
[[Category: alternative open reading frame]] | [[Category: alternative open reading frame]] | ||
[[Category: hypothetical protein]] | [[Category: hypothetical protein]] | ||
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[[Category: virus assembly]] | [[Category: virus assembly]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:23:34 2008'' |
Revision as of 23:23, 30 March 2008
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| , resolution 2.8Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CRYSTAL STRUCTURE OF SARS CORONAVIRUS ORF-9B PROTEIN
Overview
To achieve the greatest output from their limited genomes, viruses frequently make use of alternative open reading frames, in which translation is initiated from a start codon within an existing gene and, being out of frame, gives rise to a distinct protein product. These alternative protein products are, as yet, poorly characterized structurally. Here we report the crystal structure of ORF-9b, an alternative open reading frame within the nucleocapsid (N) gene from the SARS coronavirus. The protein has a novel fold, a dimeric tent-like beta structure with an amphipathic surface, and a central hydrophobic cavity that binds lipid molecules. This cavity is likely to be involved in membrane attachment and, in mammalian cells, ORF-9b associates with intracellular vesicles, consistent with a role in the assembly of the virion. Analysis of ORF-9b and other overlapping genes suggests that they provide snapshots of the early evolution of novel protein folds.
About this Structure
2CME is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus., Meier C, Aricescu AR, Assenberg R, Aplin RT, Gilbert RJ, Grimes JM, Stuart DI, Structure. 2006 Jul;14(7):1157-65. PMID:16843897
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