Syntrophin
From Proteopedia
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(New page: <StructureSection load='1qav' size='340' side='right' caption='Mouse syntrophin PDZ domain (grey) complex with neuronal NOS (green) (PDB code 1qav)' scene=''> == Function == Syntro...) |
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<StructureSection load='1qav' size='340' side='right' caption='Mouse syntrophin PDZ domain (grey) complex with neuronal NOS (green) (PDB code [[1qav]])' scene=''> | <StructureSection load='1qav' size='340' side='right' caption='Mouse syntrophin PDZ domain (grey) complex with neuronal NOS (green) (PDB code [[1qav]])' scene=''> | ||
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Mutations in Syn which interacts with sodium channel cause the inherited disorder long-QT syndrome resulting in sudden cardiac death<ref>PMID:19684871</ref>. | Mutations in Syn which interacts with sodium channel cause the inherited disorder long-QT syndrome resulting in sudden cardiac death<ref>PMID:19684871</ref>. | ||
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| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:09, 25 December 2017
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3D Structures of syntrophin
Updated on 25-December-2017
References
- ↑ Bhat HF, Adams ME, Khanday FA. Syntrophin proteins as Santa Claus: role(s) in cell signal transduction. Cell Mol Life Sci. 2013 Jul;70(14):2533-54. doi: 10.1007/s00018-012-1233-9. Epub , 2012 Dec 21. PMID:23263165 doi:http://dx.doi.org/10.1007/s00018-012-1233-9
- ↑ Wu G, Ai T, Kim JJ, Mohapatra B, Xi Y, Li Z, Abbasi S, Purevjav E, Samani K, Ackerman MJ, Qi M, Moss AJ, Shimizu W, Towbin JA, Cheng J, Vatta M. alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption. Circ Arrhythm Electrophysiol. 2008 Aug;1(3):193-201. doi:, 10.1161/CIRCEP.108.769224. PMID:19684871 doi:http://dx.doi.org/10.1161/CIRCEP.108.769224
- ↑ Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science. 1999 Apr 30;284(5415):812-5. PMID:10221915
