2co5
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2co5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2co5 OCA], [http://www.ebi.ac.uk/pdbsum/2co5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2co5 RCSB]</span> | ||
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[[Category: winged helix]] | [[Category: winged helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:24:16 2008'' |
Revision as of 23:24, 30 March 2008
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| , resolution 2.20Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
F93 FROM STIV, A WINGED-HELIX DNA-BINDING PROTEIN
Overview
Sulfolobus turreted icosahedral virus (STIV) was the first non-tailed icosahedral virus to be isolated from an archaeal host. Like other archaeal viruses, its 37 open reading frames generally lack sequence similarity to genes with known function. The roles of the gene products in this and other archaeal viruses are thus largely unknown. However, a protein's three-dimensional structure may provide functional and evolutionary insight in cases of minimal sequence similarity. In this vein, the structure of STIV F93 reveals a homodimer with strong similarity to the winged-helix family of DNA-binding proteins. Importantly, an interchain disulfide bond is found at the dimer interface, prompting analysis of the cysteine distribution in the putative intracellular proteins of the viral proteome. The analysis suggests that intracellular disulfide bonds are common in cellular STIV proteins, where they enhance the thermostability of the viral proteome.
About this Structure
2CO5 is a Single protein structure of sequence from Sulfolobus turreted icosahedral virus. Full crystallographic information is available from OCA.
Reference
A winged-helix protein from Sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus., Larson ET, Eilers B, Menon S, Reiter D, Ortmann A, Young MJ, Lawrence CM, Virology. 2007 Nov 25;368(2):249-61. Epub 2007 Jul 31. PMID:17669459
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Categories: Single protein | Sulfolobus turreted icosahedral virus | Larson, E T. | Lawrence, C M. | Reiter, D. | Archaea | Archaeal virus | Crenarchaea | Crenarchaeal virus | Disulfide bond | Dna-binding | F93 | Hth | Stiv | Sulfolobus yellowstone | Thermophilic protein | Thermophilic virus | Viral protein | Viral protein/winged helix complex | Virus | Whth | Winged helix
