5ytk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of SIRT3 bound to a leucylated AceCS2== | |
| - | + | <StructureSection load='5ytk' size='340' side='right' caption='[[5ytk]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ytk]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YTK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ytk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ytk OCA], [http://pdbe.org/5ytk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ytk RCSB], [http://www.ebi.ac.uk/pdbsum/5ytk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ytk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gong, W]] | ||
[[Category: Li, J]] | [[Category: Li, J]] | ||
| - | [[Category: Gong, W]] | ||
[[Category: Xu, Y]] | [[Category: Xu, Y]] | ||
| + | [[Category: Dna-dependent deacetylase sirtuin-3]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Leucylated acecs2]] | ||
Revision as of 08:35, 27 December 2017
Crystal structure of SIRT3 bound to a leucylated AceCS2
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