6b5v
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of TRPV5 in complex with econazole== | |
| - | + | <StructureSection load='6b5v' size='340' side='right' caption='[[6b5v]], [[Resolution|resolution]] 4.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6b5v]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B5V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b5v OCA], [http://pdbe.org/6b5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b5v RCSB], [http://www.ebi.ac.uk/pdbsum/6b5v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b5v ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRPV5_RABIT TRPV5_RABIT]] Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).[UniProtKB:P69744][UniProtKB:Q9NQA5]<ref>PMID:10085067</ref> <ref>PMID:11035011</ref> <ref>PMID:12574114</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Basak, S]] | ||
| + | [[Category: Chakrapani, S]] | ||
| + | [[Category: Filizola, M]] | ||
| + | [[Category: Han, S]] | ||
| + | [[Category: Hughes, T E.T]] | ||
| + | [[Category: Huynh, K W]] | ||
| + | [[Category: Kapoor, A]] | ||
| + | [[Category: Lodowski, D T]] | ||
| + | [[Category: Moiseenkova-Bell, V Y]] | ||
| + | [[Category: Rohacs, T]] | ||
| + | [[Category: Rosario, J del]] | ||
| + | [[Category: Samanta, A]] | ||
| + | [[Category: Yazici, A]] | ||
| + | [[Category: Zhou, Z H]] | ||
| + | [[Category: Cryo-em]] | ||
| + | [[Category: Econazole]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transient receptor potential channel]] | ||
| + | [[Category: Trpv5]] | ||
Revision as of 08:37, 27 December 2017
Structure of TRPV5 in complex with econazole
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