6bpi

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m (Protected "6bpi" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6bpi is ON HOLD
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==Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates==
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<StructureSection load='6bpi' size='340' side='right' caption='[[6bpi]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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Authors: MADER, P., Mendoza-Sanchez, R., DONG, A., DOBROVETSKY, E., IQBAL, A., CORLESS, V., TEMPEL, W., LIEW, S.K., SMIL, D., DELA SENA, C.C., KENNEDY, S., DIAZ, D.B., SCHAPIRA, M., VEDADI, M., BROWN, P.J., Santhakumar, V., FRYE, S., Bountra, C., Edwards, A.M., YUDIN, A.K., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bpi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BPI FirstGlance]. <br>
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Description: Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=E2G:'>E2G</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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[[Category: Frye, S]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6au2|6au2]], [[6au3|6au3]]</td></tr>
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[[Category: Diaz, D.B]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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[[Category: Arrowsmith, C.H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpi OCA], [http://pdbe.org/6bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bpi RCSB], [http://www.ebi.ac.uk/pdbsum/6bpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Arrowsmith, C H]]
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[[Category: BROWN, P J]]
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[[Category: Bountra, C]]
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[[Category: CORLESS, V]]
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[[Category: DIAZ, D B]]
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[[Category: DOBROVETSKY, E]]
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[[Category: DONG, A]]
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[[Category: Edwards, A M]]
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[[Category: FRYE, S]]
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[[Category: IQBAL, A]]
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[[Category: KENNEDY, S]]
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[[Category: LIEW, S K]]
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[[Category: MADER, P]]
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[[Category: Mendoza-Sanchez, R]]
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[[Category: SCHAPIRA, M]]
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[[Category: SENA, C C.DELA]]
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[[Category: Structural genomic]]
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[[Category: SMIL, D]]
[[Category: Santhakumar, V]]
[[Category: Santhakumar, V]]
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[[Category: Kennedy, S]]
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[[Category: TEMPEL, W]]
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[[Category: Iqbal, A]]
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[[Category: VEDADI, M]]
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[[Category: Dong, A]]
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[[Category: YUDIN, A K]]
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[[Category: Vedadi, M]]
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[[Category: Epigenetic]]
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[[Category: Brown, P.J]]
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[[Category: Fragment hit]]
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[[Category: Smil, D]]
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[[Category: Methyl lysine reader]]
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[[Category: Mendoza-Sanchez, R]]
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[[Category: Setdb1 tudor]]
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[[Category: Corless, V]]
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[[Category: Sgc]]
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[[Category: Liew, S.K]]
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[[Category: Transferase]]
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[[Category: Yudin, A.K]]
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[[Category: Schapira, M]]
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[[Category: Edwards, A.M]]
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[[Category: Dobrovetsky, E]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Dela Sena, C.C]]
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[[Category: Mader, P]]
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[[Category: Bountra, C]]
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[[Category: Tempel, W]]
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Revision as of 08:39, 27 December 2017

Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates

6bpi, resolution 1.64Å

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