Peptidyl-tRNA hydrolase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='450' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'> |
== Function == | == Function == | ||
'''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability. | '''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability. | ||
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**[[3v2i]] – PTH – ''Burkholderia thailandesis''<BR /> | **[[3v2i]] – PTH – ''Burkholderia thailandesis''<BR /> | ||
**[[4dhw]], [[4djj]], [[4erx]], [[4fno]], [[4fyj]], [[4jc4]], [[4qaj]] – PaPTH – ''Pseudomonas aeruginosa''<BR /> | **[[4dhw]], [[4djj]], [[4erx]], [[4fno]], [[4fyj]], [[4jc4]], [[4qaj]] – PaPTH – ''Pseudomonas aeruginosa''<BR /> | ||
| - | **[[4fop]], [[4fot]], [[4hoy]], [[4iko]], [[4jy7]], [[ | + | **[[4fop]], [[4fot]], [[4hoy]], [[4iko]], [[4jy7]], [[5y98]], [[4lwq]] – AbPTH – ''Acinetobacter baumannii''<BR /> |
**[[4olj]] – AbPTH (mutant)<BR /> | **[[4olj]] – AbPTH (mutant)<BR /> | ||
**[[4p7b]] – PTH – ''Salmonella enterica''<BR /> | **[[4p7b]] – PTH – ''Salmonella enterica''<BR /> | ||
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**[[3vjr]] – EcPTH + tRNA CCA acceptor domain<BR /> | **[[3vjr]] – EcPTH + tRNA CCA acceptor domain<BR /> | ||
| - | **[[4jwk]], [[ | + | **[[4jwk]], [[5y9a]] – AbPTH + cytidine derivative<BR /> |
**[[4qd3]] – PaPTH + cytidine derivative<BR /> | **[[4qd3]] – PaPTH + cytidine derivative<BR /> | ||
**[[4jx9]] – AbPTH + uridine<BR /> | **[[4jx9]] – AbPTH + uridine<BR /> | ||
Revision as of 20:02, 28 December 2017
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3D Structures of peptidyl-tRNA hydrolase
Updated on 28-December-2017
References
- ↑ Das G, Varshney U. Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis. Microbiology. 2006 Aug;152(Pt 8):2191-5. PMID:16849786 doi:http://dx.doi.org/10.1099/mic.0.29024-0
- ↑ Ito K, Murakami R, Mochizuki M, Qi H, Shimizu Y, Miura KI, Ueda T, Uchiumi T. Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase. Nucleic Acids Res. 2012 Aug 25. PMID:22923517 doi:10.1093/nar/gks790
