Peptidyl-prolyl cis-trans isomerase

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<StructureSection load='1f8a' size='450' side='right' caption='Human PPIase (green) complex with phosphoserine containing peptide (magenta) (PDB code [[1f8a]]).' scene='67/677404/Cv/1'>
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<StructureSection load='' size='450' side='right' caption='Human PPIase (green) complex with phosphoserine containing peptide (magenta) (PDB code [[1f8a]]).' scene='67/677404/Cv/1'>
__TOC__
__TOC__
== Function ==
== Function ==
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**[[2mc9]] – PPIase – rosy periwinkle - NMR<BR />
**[[2mc9]] – PPIase – rosy periwinkle - NMR<BR />
**[[2wlw]] – PPIase CypA domain – ''Macaca mulatta'' <BR />
**[[2wlw]] – PPIase CypA domain – ''Macaca mulatta'' <BR />
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**[[3oe2]], [[5bx0]] – PPIase – ''Pseudomonas syringae''<BR />
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**[[5xb0]] – PPIase – ''Pseudomonas syringae''<BR />
**[[4s1e]], [[4s1j]] – PPIase (mutant) – ''Leishmania donovani''<BR />
**[[4s1e]], [[4s1j]] – PPIase (mutant) – ''Leishmania donovani''<BR />
**[[2m08]] – PPIase – ''Nitrosopumilus maritimus'' - NMR<BR />
**[[2m08]] – PPIase – ''Nitrosopumilus maritimus'' - NMR<BR />

Revision as of 20:16, 28 December 2017

Human PPIase (green) complex with phosphoserine containing peptide (magenta) (PDB code 1f8a).

Drag the structure with the mouse to rotate

3D Structures of peptidyl-prolyl cis-trans isomerase

Updated on 28-December-2017

References

  1. Guito J, Gavina A, Palmeri D, Lukac DM. The cellular peptidyl-prolyl cis/trans isomerase Pin1 regulates reactivation of Kaposi's sarcoma-associated herpesvirus from latency. J Virol. 2014 Jan;88(1):547-58. doi: 10.1128/JVI.02877-13. Epub 2013 Oct 30. PMID:24173213 doi:http://dx.doi.org/10.1128/JVI.02877-13
  2. Fischer G, Bang H, Ludwig B, Mann K, Hacker J. Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity. Mol Microbiol. 1992 May;6(10):1375-83. PMID:1379319
  3. Quistgaard EM, Nordlund P, Low C. High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA. FASEB J. 2012 Jun 26. PMID:22735173 doi:10.1096/fj.12-208397
  4. McClements L, Annett S, Yakkundi A, Robson T. The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases. Curr Mol Pharmacol. 2015;9(2):165-79. PMID:25986561
  5. Westerman ST. Tasting instilled otologic drops is not a reliable test of eustachian tube function. Arch Otolaryngol Head Neck Surg. 2000 Aug;126(8):1042. PMID:10922246

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