A-kinase anchor protein

Function

A-kinase anchor proteins (AKAP) mediate the localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes by interacting with them ^[1]. AKAPs form multi-protein complexes via interaction with the regulatory subunits of PKA. These protein complexes are key molecules in the biochemical machinery regulating the function of flagella and cilia^[2].

Disease

Relevance

AKAPs play a central role in organizing signaling pathways which control cardiac contractility and rhythm as well as the pathological response of the heart to stress and other dysfunctions such as arrhythmias, cardiac hypertrophy and heart failure^[3].

Structural highlights