A-kinase anchor protein

From Proteopedia

Revision as of 11:56, 31 December 2017

spinqualitylabelsall models Human AKAP18 helix (olive) complex with a dimer of cAMP-dependent protein kinase regulatory subunit (grey and green) and Cd+2 ions (PDB code 4zp3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function A-kinase anchor proteins (AKAP) mediate the localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes by interacting with them [1]. AKAPs form multi-protein complexes via interaction with the regulatory subunits of PKA. These protein complexes are key molecules in the biochemical machinery regulating the function of flagella and cilia[2]. Relevance AKAPs play a central role in organizing signaling pathways which control cardiac contractility and rhythm as well as the pathological response of the heart to stress and other dysfunctions such as arrhythmias, cardiac hypertrophy and heart failure[3]. Structural highlights An ampiphatic helix of AKAP18 binds with its hydrophobic sides to helices of the PKA regulatory subunit[4].

3D Structures of A-kinase anchor protein

Updated on 31-December-2017

References

1. ↑ Edwards AS, Scott JD. A-kinase anchoring proteins: protein kinase A and beyond. Curr Opin Cell Biol. 2000 Apr;12(2):217-21. PMID:10712918
2. ↑ Carr DW, Newell AE. The role of A-kinase anchoring proteins (AKaps) in regulating sperm function. Soc Reprod Fertil Suppl. 2007;63:135-41. PMID:17566268
3. ↑ Diviani D, Dodge-Kafka KL, Li J, Kapiloff MS. A-kinase anchoring proteins: scaffolding proteins in the heart. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1742-53. doi:, 10.1152/ajpheart.00569.2011. Epub 2011 Aug 19. PMID:21856912 doi:http://dx.doi.org/10.1152/ajpheart.00569.2011
4. ↑ Gotz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zuhlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E. AKAP18:PKA-RIIalpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA. Biochem J. 2016 Apr 21. pii: BCJ20160242. PMID:27102985 doi:http://dx.doi.org/10.1042/BCJ20160242