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Cytochrome P450

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<StructureSection load='' size='350' side='right' caption='Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry [[1og5]])' scene='43/430105/Cv/2'>
<StructureSection load='' size='350' side='right' caption='Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry [[1og5]])' scene='43/430105/Cv/2'>
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[[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref> For details on the human P45019 family see [[Aromatase]].<br />
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[[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref>.<br />
* '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.<br />
* '''P450cam''', also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor.<br />
* '''P450nor''' is a Nitric Oxide Reductase P450.<br />
* '''P450nor''' is a Nitric Oxide Reductase P450.<br />
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* '''Bifunctional P450/NADPH P450 reductase''' (P450 BM3) is a fatty acid monooxygenase.<br />
* '''Bifunctional P450/NADPH P450 reductase''' (P450 BM3) is a fatty acid monooxygenase.<br />
* '''P450 3A4''' see [[CYP3A4]].<br />
* '''P450 3A4''' see [[CYP3A4]].<br />
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* '''P450 19 family''' see [[Aromatase]].<br />
Additional details in [[Drug Metabolism by CYP450 Enzymes]].
Additional details in [[Drug Metabolism by CYP450 Enzymes]].

Revision as of 09:34, 2 January 2018

Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry 1og5)

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3D Structures of Cytochrome P450

Updated on 02-January-2018

References

  1. ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
  2. ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862

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