5w7b
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Rabbit acyloxyacyl hydrolase (AOAH), proteolytically processed, S262A mutant, with LPS== | |
| - | + | <StructureSection load='5w7b' size='340' side='right' caption='[[5w7b]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5w7b]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W7B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FTT:3-HYDROXY-TETRADECANOIC+ACID'>FTT</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GCS:D-GLUCOSAMINE'>GCS</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PA1:2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSE'>PA1</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyloxyacyl_hydrolase Acyloxyacyl hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.77 3.1.1.77] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w7b OCA], [http://pdbe.org/5w7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w7b RCSB], [http://www.ebi.ac.uk/pdbsum/5w7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w7b ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AOAH_RABIT AOAH_RABIT]] Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses. In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria.[UniProtKB:O35298] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acyloxyacyl hydrolase]] | ||
| + | [[Category: Gorelik, A]] | ||
| + | [[Category: Illes, K]] | ||
| + | [[Category: Nagar, B]] | ||
| + | [[Category: Gdsl esterase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Lipopolysaccharide]] | ||
| + | [[Category: Lp]] | ||
| + | [[Category: Saposin]] | ||
Revision as of 05:47, 3 January 2018
Rabbit acyloxyacyl hydrolase (AOAH), proteolytically processed, S262A mutant, with LPS
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