5w7f

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m (Protected "5w7f" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5w7f is ON HOLD until Paper Publication
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==Murine acyloxyacyl hydrolase (AOAH), S262A mutant, with lipid A==
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<StructureSection load='5w7f' size='340' side='right' caption='[[5w7f]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5w7f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W7F FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=FTT:3-HYDROXY-TETRADECANOIC+ACID'>FTT</scene>, <scene name='pdbligand=GCS:D-GLUCOSAMINE'>GCS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyloxyacyl_hydrolase Acyloxyacyl hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.77 3.1.1.77] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w7f OCA], [http://pdbe.org/5w7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w7f RCSB], [http://www.ebi.ac.uk/pdbsum/5w7f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w7f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/AOAH_MOUSE AOAH_MOUSE]] Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055).<ref>PMID:12810692</ref> <ref>PMID:15155618</ref> <ref>PMID:17322564</ref> <ref>PMID:18779055</ref> <ref>PMID:19860560</ref> <ref>PMID:28622363</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Acyloxyacyl hydrolase]]
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[[Category: Gorelik, A]]
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[[Category: Illes, K]]
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[[Category: Nagar, B]]
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[[Category: Gdsl esterase]]
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[[Category: Hydrolase]]
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[[Category: Lipopolysaccharide]]
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[[Category: Lp]]
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[[Category: Saposin]]

Revision as of 05:47, 3 January 2018

Murine acyloxyacyl hydrolase (AOAH), S262A mutant, with lipid A

5w7f, resolution 2.80Å

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