2cw3
From Proteopedia
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|PDB= 2cw3 |SIZE=350|CAPTION= <scene name='initialview01'>2cw3</scene>, resolution 2.50Å | |PDB= 2cw3 |SIZE=350|CAPTION= <scene name='initialview01'>2cw3</scene>, resolution 2.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=FE:FE (III) ION'>FE</scene> | + | |LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2cw2|2cw2]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw3 OCA], [http://www.ebi.ac.uk/pdbsum/2cw3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cw3 RCSB]</span> | ||
}} | }} | ||
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[[Category: Silva, A M.]] | [[Category: Silva, A M.]] | ||
[[Category: Vasta, G R.]] | [[Category: Vasta, G R.]] | ||
| - | [[Category: FE]] | ||
[[Category: sod]] | [[Category: sod]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:27:10 2008'' |
Revision as of 23:27, 30 March 2008
| |||||||
| , resolution 2.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Superoxide dismutase, with EC number 1.15.1.1 | ||||||
| Related: | 2cw2
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray structure of PmSOD2, superoxide dismutase from Perkinsus marinus
Overview
Perkinsus marinus, a facultative intracellular parasite of the eastern oyster Crassostrea virginica, is responsible for mass mortalities of oyster populations. P. marinus trophozoites survive and proliferate within oyster hemocytes, invading most tissues and fluids, thus causing a systemic infection that eventually kills the host. The phagocytosis of P. marinus trophozoites lacks a respiratory burst, suggesting that the parasite has mechanisms that actively abrogate the host's oxidative defense responses. One mechanism and the first line of defense against oxidative damage is the dismutation of superoxide radical to molecular oxygen and hydrogen peroxide by superoxide dismutases (SODs). P. marinus possesses two iron-cofactored SODs, PmSOD1 and PmSOD2. Here, the crystallization and X-ray structures of both PmSOD1 and PmSOD2 are presented.
About this Structure
2CW3 is a Single protein structure of sequence from Perkinsus marinus. Full crystallographic information is available from OCA.
Reference
Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus., Asojo OA, Schott EJ, Vasta GR, Silva AM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1072-5. Epub 2006 Oct 25. PMID:17077482
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