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5nw9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the complex of Tdp1 with duplex DNA== | |
| - | + | <StructureSection load='5nw9' size='340' side='right' caption='[[5nw9]], [[Resolution|resolution]] 2.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nw9]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NW9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nw9 OCA], [http://pdbe.org/5nw9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nw9 RCSB], [http://www.ebi.ac.uk/pdbsum/5nw9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nw9 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Richardson, J | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1) [MIM:[http://omim.org/entry/607250 607250]]. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.<ref>PMID:16141202</ref> <ref>PMID:15647511</ref> <ref>PMID:12244316</ref> <ref>PMID:17948061</ref> <ref>PMID:15920477</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Morris, E R]] | ||
| + | [[Category: Richardson, J M]] | ||
[[Category: Ruksenaite, E]] | [[Category: Ruksenaite, E]] | ||
| - | [[Category: | + | [[Category: Dna repair]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Nucleosidase]] | ||
| + | [[Category: Phosphotyrosine diesterase]] | ||
| + | [[Category: Protein-dna complex]] | ||
Revision as of 08:21, 10 January 2018
Crystal structure of the complex of Tdp1 with duplex DNA
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