6ax2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of Magi3 a specific insect toxin from the spider Macrothele gigas== | |
| + | <StructureSection load='6ax2' size='340' side='right' caption='[[6ax2]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ax2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AX2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ax2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ax2 OCA], [http://pdbe.org/6ax2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ax2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ax2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ax2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The need for molecules with high specificity against noxious insects leads the search towards spider venoms that have evolved highly selective toxins for insect preys. In this respect, spiders as a highly diversified group of almost exclusive insect predators appear to possess infinite potential for the discovery of novel insect-selective toxins. In 2003, a group of toxins was isolated from the spider Macrothele gigas and the amino acid sequence was reported. We obtained, by molecular biology techniques in a heterologous system, one of these toxins. Purification process was optimized by chromatographic methods to determine the three-dimensional structure by nuclear magnetic resonance in solution, and, finally, their biological activity was tested. rMagi3 resulted to be a specific insect toxin with no effect on mice. | ||
| - | + | Successful refolding and NMR structure of rMagi3: a disulfide-rich insecticidal spider toxin.,Titaux-Delgado G, Carrillo E, Mendoza A, Mayorga-Flores M, Escobedo-Gonzalez FC, Cano-Sanchez P, Lopez-Vera E, Corzo G, Del Rio-Portilla F Protein Sci. 2017 Dec 16. doi: 10.1002/pro.3363. PMID:29247580<ref>PMID:29247580</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6ax2" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Delgado, G A.Titaux]] | ||
| + | [[Category: Gonzalez, F C.Escobedo]] | ||
| + | [[Category: Portilla, F del Rio]] | ||
| + | [[Category: Insecticidal peptide]] | ||
| + | [[Category: Refolding]] | ||
| + | [[Category: Spider toxin]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 08:30, 10 January 2018
Solution structure of Magi3 a specific insect toxin from the spider Macrothele gigas
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