5jaw
From Proteopedia
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<StructureSection load='5jaw' size='340' side='right' caption='[[5jaw]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='5jaw' size='340' side='right' caption='[[5jaw]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5jaw]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JAW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5jaw]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Celju Celju]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JAW FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UUU:(1S,2S,3S,4S,5R,6R)-5-AMINO-6-(HYDROXYMETHYL)CYCLOHEXANE-1,2,3,4-TETROL'>UUU</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UUU:(1S,2S,3S,4S,5R,6R)-5-AMINO-6-(HYDROXYMETHYL)CYCLOHEXANE-1,2,3,4-TETROL'>UUU</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bgl35A, CJA_2707 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=498211 CELJU])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactosidase Beta-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.23 3.2.1.23] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jaw OCA], [http://pdbe.org/5jaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jaw RCSB], [http://www.ebi.ac.uk/pdbsum/5jaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jaw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jaw OCA], [http://pdbe.org/5jaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jaw RCSB], [http://www.ebi.ac.uk/pdbsum/5jaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jaw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of beta-glucosidases and beta-galactosidases. | ||
| + | |||
| + | Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.,Schroder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codee JDC, van der Marel GA, Overkleeft HS Chem Commun (Camb). 2017 Nov 21;53(93):12528-12531. doi: 10.1039/c7cc07730k. PMID:29116266<ref>PMID:29116266</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5jaw" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Beta-galactosidase]] | [[Category: Beta-galactosidase]] | ||
| + | [[Category: Celju]] | ||
[[Category: Davies, G]] | [[Category: Davies, G]] | ||
[[Category: Offen, W]] | [[Category: Offen, W]] | ||
Revision as of 08:36, 10 January 2018
Structure of a beta galactosidase with inhibitor
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