5mr4

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'''Unreleased structure'''
 
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The entry 5mr4 is ON HOLD until Paper Publication
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==Ligand-receptor complex.==
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<StructureSection load='5mr4' size='340' side='right' caption='[[5mr4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5mr4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MR4 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mr5|5mr5]], [[5nmz|5nmz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mr4 OCA], [http://pdbe.org/5mr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mr4 RCSB], [http://www.ebi.ac.uk/pdbsum/5mr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mr4 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/NRTN_HUMAN NRTN_HUMAN]] Hirschsprung disease. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.<ref>PMID:9700200</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/NRTN_HUMAN NRTN_HUMAN]] Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. [[http://www.uniprot.org/uniprot/GFRA2_HUMAN GFRA2_HUMAN]] Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.[UniProtKB:O08842]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aagaard, A]]
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[[Category: Dahl, G]]
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[[Category: Oster, L]]
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[[Category: Roth, R G]]
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[[Category: Sandmark, J]]
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[[Category: Complex]]
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[[Category: Receptor]]
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[[Category: Signaling protein]]
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[[Category: Signalling]]

Revision as of 06:47, 17 January 2018

Ligand-receptor complex.

5mr4, resolution 2.40Å

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