5mrv
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human carboxypeptidase O in complex with NvCI== | |
| - | + | <StructureSection load='5mrv' size='340' side='right' caption='[[5mrv]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mrv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MRV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrv OCA], [http://pdbe.org/5mrv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mrv RCSB], [http://www.ebi.ac.uk/pdbsum/5mrv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrv ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CBPO_HUMAN CBPO_HUMAN]] Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues.<ref>PMID:21921028</ref> [[http://www.uniprot.org/uniprot/MCPI_NERVS MCPI_NERVS]] Metallocarboxypeptidase inhibitor. Has an inhibitory effect on bovine CPA1 and CPB2, human CPA1, CPA2, CPA4, CPB1 and CPB2, and porcine CPB1. Does not inhibit D.melanogaster svr (carboxypeptidase D). Shows no activity against serine proteases subtilisin or bovine trypsin, cysteine protease papain, and aspartyl protease porcine pepsin.<ref>PMID:22294694</ref> [UniProtKB:P01075] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aviles, F X]] | ||
| + | [[Category: Fernandez-Alvarez, R]] | ||
| + | [[Category: Garcia-Guerrero, M C]] | ||
| + | [[Category: Garcia-Pardo, J]] | ||
[[Category: Lorenzo, J]] | [[Category: Lorenzo, J]] | ||
| - | [[Category: | + | [[Category: Lyons, P]] |
[[Category: Reverter, D]] | [[Category: Reverter, D]] | ||
| - | [[Category: | + | [[Category: Brush border enzyme]] |
| - | [[Category: | + | [[Category: Carboxypeptidase inhibitor]] |
| - | [[Category: | + | [[Category: Digestive metallocarboxypeptidase]] |
| - | [[Category: | + | [[Category: Food digestion]] |
| + | [[Category: Hydrolase]] | ||
Revision as of 06:48, 17 January 2018
Crystal structure of human carboxypeptidase O in complex with NvCI
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