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5w8f
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14== | |
| - | + | <StructureSection load='5w8f' size='340' side='right' caption='[[5w8f]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5w8f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W8F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr> |
| - | [[Category: Jenson, J | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5w89|5w89]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w8f OCA], [http://pdbe.org/5w8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w8f RCSB], [http://www.ebi.ac.uk/pdbsum/5w8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w8f ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Araghi, R Rezaei]] | ||
| + | [[Category: Grant, R A]] | ||
| + | [[Category: Jenson, J M]] | ||
| + | [[Category: Keating, A E]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Bcl-2 family]] | ||
| + | [[Category: Bh3 domain]] | ||
| + | [[Category: Peptide binding protein]] | ||
| + | [[Category: Stapled peptide]] | ||
Revision as of 06:54, 17 January 2018
Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14
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